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4/5/1952

O Criador

Bhetwal, Bhupal

Further Elucidation of the Role of Protein Kinase-C and Rho Kinase in the Mechanism of Action of Bitter Melon Extract on Human Metastatic Breast Cancer Cells

Correspondências de palavras-chave:

O Criador:

Noe, Leah and Bhetwal, Bhupal

Descrição:

Introduction: It is well documented in the literature that Bitter Melon Extract (BME) inhibits the growth and proliferation of MCF-7 breast cancer cells. While the exact mechanism of this inhibition is unknown, it is possible...

Tipo:

poster
Role of Protein Kinase-C and Rho Kinase in the Cytotoxic Effects of Bitter Melon Extract on Metastatic Breast Cancer Cells

Correspondências de palavras-chave:

... Thr696 P P 38Thr _ BME 0.5% 2% 1% Figure 5. BME dose-dependently prevents drop in pH in culture medium ...

... suggesting less metabolism Figure 4. BME dose-dependently decreases glucose clearance from culture medium ...

... Figure 6. BME dose-dependently decreases viability of MCF-7 cells Glucose Measurement (N=4) 500 400 ...

... * * * 300 200 100 (v/v) 0 no BME 0.50% 1% 2% 5% 10% Cell division MCF-7 Cell Viability (N=3) 1.2 1 0.8 0.6 ...

... 0.4 0.2 0 * * * no BME 0.50% Dose of BME (v/v) MYPT1 Cell migration Cell viability 1% 2% * * 5% 10 ...

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O Criador:

Bhetwal, Bhupal and Choi, Heeyun

Descrição:

Introduction: Bitter melon extract (BME) is known to inhibit breast cancer cells (MCF-7) proliferation. The PKC and ROK play critical roles in cell division, migration, and survival. However, the roles of protein kinase-c (PKC)...

Tipo:

poster

Further Elucidation of the Role of Protein Kinase-C and Rho Kinase in the Mechanism of Action of Bitter Melon Extract on Human Metastatic Breast Cancer Cells

Role of Protein Kinase-C and Rho Kinase in the Cytotoxic Effects of Bitter Melon Extract on Metastatic Breast Cancer Cells

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