... . Interestingly, blockade of mTORC1 and -2 by Torin2 decreased CXCR4-mediated migration but had no effect on 1060 ...
... . Inhibition of mTOR complex 1 (mTORC1) by rapamycin [drug concentration causing 50% inhibition (IC50) = 5 nM ...
... ] and mTORC1/ mTORC2 by Torin2 (IC50 = 6 nM), or by knocking down key mTORC1/2 components, Raptor and ...
... rapamycin. In contrast, disrupting mTORC2 had no effect in tumor growth or metastasis compared with control ...
... , which are divided in 2 groups depending on their function: inammatory and homeostatic. Inammatory ...