Cho, Tim and Lowery, Jonathan

The Activin and BMP signaling pathways exert reciprocal effects on myogenesis and skeletal muscle regeneration after injury. Signal transduction in both pathways is mediated by ligand- induced activation of transcriptional...

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Christopher, Hannah and Dufeau, David

Context: Though anatomy is a vital part of a medical student’s education, three-dimensional visualization often ends in the laboratory, months into a medical student’s journey to becoming a physician. Many physicians would...

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Alibegovic, Kenan, Daggett, James, Narra, Seetharam, Wilson, Thad, Metzler-Wilson, Kristen, Kocherlakota, Uma, and Fang, Milie

30 cm from heart level; CVAR), venoarteriolar response plus a decrease in perfusion pressure (venous occlusion by proximal cuff inflation; CVAR with DPP), and ischemia (arterial occlusion by proximal cuff inflation) and sweat...

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Alibegovic, Kenan, Metzler-Wilson, Kristen, Daggett, James, Wilson, Thad, and Fang, Milie

1.0°C. Arm and leg SkBF (laser-Doppler flowmetry) was decreased by engaging the venoarteriolar response (limb lowered ~30 cm from heart level; CVAR), venoarteriolar response plus a decrease in perfusion pressure (venous...

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Chlebek, Sylvia, Arthur, Jon, Newby, Jordan, and Lowery, Jonathan

Osteoporosis is a disease characterized by low bone mineral density due to the rate of bone resorption exceeding that of bone formation. Substantial evidence indicates the Bone Morphogenetic Protein (BMP) pathway promotes bone...

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Shadmand, Mehdi, Lucas, Tyler, Kelly, Madison, Hum, Julia, and Sharma, Curren Robling, Alexander

Context: In states of health, bone mass is sustained in a coordinated effort by osteoblasts, osteoclasts, and osteocytes. WNT signaling through low-density lipoprotein receptor related protein 5/6 (LRP5/LRP6) is one of the...

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Zahl, Sarah, Kirby, Conor, Kisby, Glen, Nallamala, Hinduja, Kaneshiro, Kelly, Lowery, Jonathan, and Nguyen, Victoria

There are limited data regarding the level of research experience and/or interest among osteopathic medical students despite a rapidly increasing enrollment and expansion of the number of osteopathic medical schools. A 2016...

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Grice, Brian, Lei, Wei, Powell, Mackenzie, Boehm, Stephen, Greve, Katherynne, Elmendorf, Jeffrey, and Vigil, Daniel

Insulin resistance is associated with a high cumulative risk of AD and reduced cerebral glucose metabolism. New data suggest that increased hexosamine biosynthesis pathway (HBP) activity induces insulin resistance in adipose...

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Gorrell, Ruthann, Hudnall, Aaron, Schoerning, Laura, Lawless, Warren, Newby, Jordan, Lowery, Jonathan, and Hum, Julia

Osteoporosis, a disease of low bone mineral density, affects 10 million Americans and triggers significant health problems and considerable socioeconomic burdens. Current treatments for osteoporosis have significant...

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Hudnall, Aaron, Lowery, Jonathan, and Jackson, Krista

Osteoporosis is a disease of low bone mass resulting from bone resorption exceeding bone formation that places individuals at enhanced risk for fracture, disability, and death. There is an urgent and unmet need for novel...

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