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Genetic Predisposition to Disease

Keyword

Bone Morphogenetic Protein Receptors

Increased Susceptibility to Hypoxic Pulmonary Hypertension in Bmpr2 Mutant Mice is Associated with Endothelial Dysfunction in the Pulmonary Vasculature

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Creator:

Brink, M., Frank, D.B., Reese, J., Lowery Jonathan W., Anderson, L., and de Caestecker, M.

Description:

Patients with familial pulmonary arterial hypertension inherit heterozygous mutations of the type 2 bone morphogenetic protein (BMP) receptor BMPR2. To explore the cellular mechanisms of this disease, we evaluated the pulmonary...

Type:

Article