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Vol. 50, No.2

Publisher

Federation of American Societies for Experimental Biology (FASEB)

Resource Type

Article

SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.

Keyword matches:

... . Interestingly, blockade of mTORC1 and -2 by Torin2 decreased CXCR4-mediated migration but had no effect on 1060 ...

... . Inhibition of mTOR complex 1 (mTORC1) by rapamycin [drug concentration causing 50% inhibition (IC50) = 5 nM ...

... ] and mTORC1/ mTORC2 by Torin2 (IC50 = 6 nM), or by knocking down key mTORC1/2 components, Raptor and ...

... rapamycin. In contrast, disrupting mTORC2 had no effect in tumor growth or metastasis compared with control ...

... , which are divided in 2 groups depending on their function: inammatory and homeostatic. Inammatory ...

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Creator:

Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia

Description:

Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...

Type:

Article