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5/12/1955

Publisher

Federation of American Societies for Experimental Biology (FASEB)

SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.

Keyword matches:

... (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cellderived factor 1/C-X-C motif chemokine 12), to ...

... . Inhibition of mTOR complex 1 (mTORC1) by rapamycin [drug concentration causing 50% inhibition (IC50) = 5 nM ...

... Abbreviations: CXCL12, C-X-C motif chemokine 12; CXCR4, C-X-C motif chemokine receptor type 4; EGF, epidermal ...

... to the homeostatic C-X-C motif chemokine 12 (CXCL12, also known as stromal cellderived factor 1, or ...

... in clinical trials (5, 6). Although effective in decreasing metastatic disease, CXCR4 inhibitors ...

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Creator:

Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia

Description:

Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...

Type:

Article