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Published by Elsevier Inc.

A founder CHEK2 pathogenic variant in association with kidney cancer

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Creator:

Holman, M, Steding, Catherine, Tucker, M, and Brooks, K

Description:

The gene CHEK2 is located at 22q12.1 and codes for the protein checkpoint kinase 2, a protein that functions in cell cycle regulation and is a known tumor suppressor. CHEK2 is activated due to DNA damage generating a cascade of...

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Article