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10.1371/journal.pone.0057840

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  • Comparative Genomics Identifies the Mouse BMP3 Promoter and an Upstream Evolutionary Conserved Region (ECR) in Mammals.

    Corrispondenze di parole chiave:
    ... Region (ECR) in Mammals. PLoS ONE 8(2): e57840. doi:10.1371/journal.pone.0057840 Editor: Bernd Sokolowski ...
    ... indicates 59-end of Bmp3 exon 1 in M. musculus. doi:10.1371/journal.pone.0057840.g001 and R. norvegicus ...
    ... 20.800 kb fragment. doi:10.1371/journal.pone.0057840.g002 To determine the function of the Bmp3 CoreECR ...
    ... . norvegicus, H. sapiens, and B. taurus are based upon the primary assembly. doi:10.1371/journal.pone.0057840 ...
    ... control and by b versus 20.800 kb fragment. doi:10.1371/journal.pone.0057840.g004 (ESTs), which comprise ...

    Creatore:

    LaVigne, AW, Kokabu, S, Lowery, Jonathan W., and Rosen, V.

    Descrizione:

    The Bone Morphogenetic Protein (BMP) pathway is a multi-member signaling cascade whose basic components are found in all animals. One member, BMP3, which arose more recently in evolution and is found only in deuterostomes,...

    Tipo di risorsa:

    Article

  • Epidermal Loss of Gag Confers a Migratory and Differentiation Defect in Keratinocytes

    Corrispondenze di parole chiave:
    ... pathologic conditions. PLOS ONE | https://doi.org/10.1371/journal.pone.0173692 March 16, 2017 1 / 18 ...
    ... mice used were in C57BL/6 PLOS ONE | https://doi.org/10.1371/journal.pone.0173692 March 16, 2017 2 / 18 ...
    ... /journal.pone.0173692.t001 PLOS ONE | https://doi.org/10.1371/journal.pone.0173692 March 16, 2017 3 / 18 ...
    ... Axio PLOS ONE | https://doi.org/10.1371/journal.pone.0173692 March 16, 2017 4 / 18 Epidermal loss of ...
    ... (Ki67), and differentiation (K10). https://doi.org/10.1371/journal.pone.0173692.g001 PLOS ONE | https ...

    Creatore:

    Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan

    Descrizione:

    G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...

    Tipo di risorsa:

    Article

  • Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension

    Corrispondenze di parole chiave:
    ... :10.1371/journal.pone.0080319 Editor: Philip Michael Bauer, University of Pittsburgh School of Medicine ...
    ... : 10.1371/journal.pone.0080319.g001 PLOS ONE | www.plosone.org 4 November 2013 | Volume 8 | Issue 11 ...
    ... ). doi: 10.1371/journal.pone.0080319.g003 the endoplasmic reticulum (ER) and Golgi apparatus. N-linked ...
    ... additional chemical chaperone, TUDCA doi: 10.1371/journal.pone.0080319.g002 cultured lymphocytes, the 130 kDa ...
    ... controls from three independent experiments. doi: 10.1371/journal.pone.0080319.g004 BMP signaling defects ...

    Creatore:

    Frump, A.L., Hamid, R., de Caestecker, M., Austin, E.D., and Lowery, Jonathan W.

    Descrizione:

    More than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). More severe clinical outcomes occur in patients with BMPR2...

    Tipo di risorsa:

    Article