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4/1/2015

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  • ABT-510 is an effective chemopreventive agent in the mouse 4-nitroquinoline 1-oxide model of oral carcinogenesis.

    Correspondências de palavras-chave:
    ... Research ABT-510 Is an Effective Chemopreventive Agent in the Mouse 4-Nitroquinoline 1-Oxide Model of Oral ...
    ... with preventive strategies. Using the 4-nitroquinoline 1-oxide (4-NQO) mouse model, we sought to define ...
    ... progression in an animal model whose genome is most similar to humans (1922). Although the 4-nitroquinoline 1 ...
    ... in mice with 4-nitroquinolone-1-oxide. Oral Surg Oral Med Oral Pathol 1984;57:52431. 13. Hawkins BL ...
    ... . Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous ...

    O Criador:

    Martin, Leslie E., Jones, Colleen L., Hasina, Rifat, Jalil, Asif, Lingen, Mark W., and Kasza, Kristen

    Descrição:

    Despite numerous advances, the 5-year survival rate for head and neck squamous cell cancer (HNSCC) has remained largely unchanged. This poor outcome is due to several variables, including the development of multiple primary...

    Tipo:

    Article

  • Loss of BMPR2 Leads to High Bone Mass Due to Increased Osteoblast Activity

    Correspondências de palavras-chave:
    ... Science (2015) 128, 13081315 doi:10.1242/jcs.156737 density in the tibia by 9 weeks of age (Table 1; Fig ...
    ... increased bone formation rate. (A) Representative histological (1, 3) and mCT (2, 4) images of female 9-week ...
    ... -old Bmpr2-floxed (1, 2) and Bmpr2-cKO (3, 4) mice. The yellow arrowhead indicates increased trabecular ...
    ... 2015. Published by The Company of Biologists Ltd | Journal of Cell Science (2015) 128, 13081315 ...
    ... de Caestecker, 2010). The 1 Department of Biomedical Science, Marian University College of ...

    O Criador:

    Ote, S., Cox, K., Baron, R., Intini, G., Salazar, V., Gamer, L., Lotinun, S., Rosen, V., and Lowery, Jonathan W.

    Descrição:

    Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGF? signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors...

    Tipo:

    Article

  • Single-Center Denial Reasons for Potential Living Kidney Donors

    Correspondências de palavras-chave:
    ... Psychosocial Decision pending 8/12-1 2/12 n = 88 54 (61%) 7 (8%) 4 (5%) 0 0 23 (26%) 17 (74%) 6 ...
    ... Hypertension 2 Kidney anatomy 6 Function 2 Stone disease 1 Diabetes 2 Obesity 4 Tumors 0 Pulmonary 0 ...
    ... 30-3 9 2 11 4 1 0 8 0 2 14 5 47 1/15-6 /15 n = 114 63 (55%) 5 (4%) 2 (2%) 0 2 (2%) 29 ...
    ... (25%) 24 (83%) 5 (17%) 13 (11%) 40-4 9 4 8 5 2 1 8 0 1 1 8 38 Total n = 644 n = 338 n ...
    ... = 67 n = 17 n = 2 n = 3 n = 202 n = 170 n = 34 n = 13 50-5 5 5 6 7 4 0 3 1 ...

    O Criador:

    Lien, Savahanna, Matas, Arthur, Voges, Margaret, and Garvey, Cathy

    Descrição:

    Because of the benefits of preemptive living donor (LD) transplant, the desire for LD is rising. However, in the last decade, there has been no increase in LD in the U.S, possibility due to older donor candidate population...

    Tipo:

    poster

  • Therapeutic Discovery for Friedreich Ataxia Using Random shRNA Selection

    Correspondências de palavras-chave:
    ... Therapeutic discovery for Friedreich ataxia using random shRNA selection Avinash 1 Kaur , M ...
    ... . Grazia 1 Cotticelli , Shujuan 1 Abstract 1 2 Xia , Fabio Acquaviva , Elisabetta 1 1 Manduchi ...
    ... , Christopher Stoeckert , Yongping 3 1 Wang , Robert B. Wilson Perelman School of Medicine at ...
    ... Materials and Methods Identification of Drug Target and Drug Background Candidate 1 ...
    ... disorder, with a prevalence of approximately 1 in 40,000 in European populations ...

    O Criador:

    Kaur, Avinash, Cotticelli, M., and Xia, Shujuan

    Descrição:

    2 fold, either as a vector-expressed shRNA or as a transfected siRNA. We randomly mutagenized gFA2 to create a gFA2 variant sub-library. We screened this sub-library in primary FA fibroblasts and identified two gFA2 variants,...

    Tipo:

    poster

  • Loss of BMPR2 Expression in Skeletal Progenitor Cells Reduces Age-Related Bone Loss

    Correspondências de palavras-chave:
    ... . Aaron M. 1 Hudnall , Jordan B. 1, 2 Newby , Vicki 3 Rosen , Jonathan W. 1 Lowery = -39.4 mgHA/ccm CI ...
    ... . = -71.11 mgHA/ccm CI: -67.4,-74.8 vBMD (mgHA/ccm) vBMD (mgHA/ccm) Conclusions: vBMD (mgHA/ccm) Fig. 1 ...
    ... Bmpr2fl/fl; Prx1-Cre+ males with Bmpr2fl/fl females (Lowery et al., Journal of Cell Science 2015). At ...
    ... -week-old humerii (Lowery et al., Journal of Cell Science 2015). B, C: As previously reported (Lowery et ...
    ... al., Journal of Cell Science 2015), osteoblast density (B) using standard analysis of number of ...

    O Criador:

    Rosen, Vickie, Hudnall, Aaron, Eaton, Michael, Newby, Jordan, and Lowery, Jonathan

    Descrição:

    Osteoporosis is a disease of low bone mineral density (BMD) that affects 10 million Americans with an additional 34 million at risk for developing the disease. Current FDA-approved therapies for osteoporosis involve...

    Tipo:

    poster

  • Comparison of Patient Tolerance of Photodynamic Therapy with Zone vs. Full Face Treatment

    Correspondências de palavras-chave:
    ... ) for their PDT treatments. Treatments were separated by 3-4 weeks. Full face was defined as the entire ...
    ... asked the following questions: 1. Grade their tolerance of the treatment regimen as Excellent, Fair, or ...
    ... improved with zone therapy, the increase in cost of the procedure should not be ignored. Table 1 Patient ...
    ... % (4) 77.9% (180/231) 17.3% (40) 4.8% (11) <0.0001 For the Zone Treatment Group, Zones were defined as ...
    ... contact 24 19 Table 2 Would Patient Repeat Treatment Zone Treatment Full Face Treatment P-value 1. Zone A ...

    O Criador:

    Crawford, Dr. Kevin and Aleshaki, Joseph

    Descrição:

    Background: Zone based photodynamic therapy (PDT) is a promising treatment option for actinic keratosis, superficial basal cell carcinoma, and in-situ squamous cell carcinoma. PDT has similar cure rates to 5-fluorouracil and...

    Tipo:

    poster

  • Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption

    Correspondências de palavras-chave:
    O Criador:

    Eaton, Michael and Newby, Jordan

    Descrição:

    Background: The Taste receptor, type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient needs. TAS1R member 3 (TAS1R3) either recognizes amino acids such as glycine and...

    Tipo:

    poster

  • Construction and Validation of a Novel Pathway Ratio Reporter System (PARRES)

    Correspondências de palavras-chave:
    O Criador:

    Ote, Satoshi, King, Tyler, Lowery, Jonathan, and Rosen, Vickie

    Descrição:

    The Transforming Growth Factor-beta (TGFβ) superfamily is a large group of signaling molecules whose members play conserved roles in embryo specification, organogenesis, and tissue homeostasis. Structural considerations...

    Tipo:

    poster

  • Coding DNA into Music: An Alternate Way of Analysis

    Correspondências de palavras-chave:
    O Criador:

    Fesenmeier, Sam

    Descrição:

    In the study, we are analyzing the human genome in order to determine patterns that may tell something about how DNA functions. Patterns require an explanation: it is highly improbable that they are random occurrence. These...

    Tipo:

    poster

  • Utility of a Scoring Tool for Living Kidney Donor Volunteers

    Correspondências de palavras-chave:
    ... scoring tool in the early assessment of LKDVs. From January-August 2015, the ...
    O Criador:

    Lien, Savahanna, Wiley, Linda, Stepan, Rebecca, Voges, Margaret, Dunn, Ty, and Lecuyer-Koich, Anne

    Descrição:

    A comprehensive yet efficient evaluation of living kidney donor volunteers (LKDV) is key to a successful transplant program. Donor selection is complex and must balance donor medical suitability, compatibility issues and donor...

    Tipo:

    poster