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A Putative PPAR d/g Agonist Induces Apoptotic Cell Death in Human Cancer Cell Lines

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MLA citation style (9th ed.)

Ristic, M, et al. A Putative Ppar D/g Agonist Induces Apoptotic Cell Death In Human Cancer Cell Lines. . 1192. marian.hykucommons.org/concern/generic_works/49b4bdb7-a58d-40df-af56-5f703b39aba4.

APA citation style (7th ed.)

R. M, R. R, B. T, G. S, B. H, F. A, D. A, & S. David. (1192). A Putative PPAR d/g Agonist Induces Apoptotic Cell Death in Human Cancer Cell Lines. https://marian.hykucommons.org/concern/generic_works/49b4bdb7-a58d-40df-af56-5f703b39aba4

Chicago citation style (CMOS 17, author-date)

Ristic, M., Rahman, R., Boncher, T., Gleason, S., Brinkman, H., Fein, A., Do, A. et al. A Putative Ppar D/g Agonist Induces Apoptotic Cell Death In Human Cancer Cell Lines. 1192. https://marian.hykucommons.org/concern/generic_works/49b4bdb7-a58d-40df-af56-5f703b39aba4.

Note: These citations are programmatically generated and may be incomplete.

Development of new and highly tailored chemotherapeutic agents continues to be the mainstay for innovative clinical treatment of cancer. Peroxisome proliferator-activated receptors (PPARs), part of a nuclear hormone super family, include multiple subtypes (α, β/δ and g) whose proteins serve a function in cell growth and differentiation. PPARδ is also a potential downstream target of the tumor suppressor gene adenomatous polyposis coli (APC), most commonly found mutated in a variety of solid tumor cancers. This makes PPAR a potential target for chemotherapeutic intervention as PPAR activation promotes tumor genesis by increasing cell proliferation. Since there is a relationship between PPAR activation and cancer, we sought to evaluate a novel PPAR δ/g agonist and explore whether this compound could alter apoptosis induced with known chemotherapeutic compounds.

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