A Putative PPAR d/g Agonist Induces Apoptotic Cell Death in Human Cancer Cell Lines
Public DepositedMLA citation style (9th ed.)
. 1192. marian.hykucommons.org/concern/generic_works/49b4bdb7-a58d-40df-af56-5f703b39aba4?q=9/11/2013. A Putative Ppar D/g Agonist Induces Apoptotic Cell Death In Human Cancer Cell Lines.APA citation style (7th ed.)
(1192). A Putative PPAR d/g Agonist Induces Apoptotic Cell Death in Human Cancer Cell Lines. https://marian.hykucommons.org/concern/generic_works/49b4bdb7-a58d-40df-af56-5f703b39aba4?q=9/11/2013Chicago citation style (CMOS 17, author-date)
A Putative Ppar D/g Agonist Induces Apoptotic Cell Death In Human Cancer Cell Lines. 1192. https://marian.hykucommons.org/concern/generic_works/49b4bdb7-a58d-40df-af56-5f703b39aba4?q=9/11/2013.Note: These citations are programmatically generated and may be incomplete.
Development of new and highly tailored chemotherapeutic agents continues to be the mainstay for innovative clinical treatment of cancer. Peroxisome proliferator-activated receptors (PPARs), part of a nuclear hormone super family, include multiple subtypes (α, β/δ and g) whose proteins serve a function in cell growth and differentiation. PPARδ is also a potential downstream target of the tumor suppressor gene adenomatous polyposis coli (APC), most commonly found mutated in a variety of solid tumor cancers. This makes PPAR a potential target for chemotherapeutic intervention as PPAR activation promotes tumor genesis by increasing cell proliferation. Since there is a relationship between PPAR activation and cancer, we sought to evaluate a novel PPAR δ/g agonist and explore whether this compound could alter apoptosis induced with known chemotherapeutic compounds.
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